Characteristics of Tianeptine Exposures Reported to the National Poison Data System – United States, 2000—2017
August 2018
What is already known about this topic?
Tianeptine is an antidepressant drug that is not approved by the Food and Drug Administration (FDA). Clinical effects of tianeptine abuse and withdrawal can mimic opioid toxicity and withdrawal.
What is added by this report?
Tianeptine exposure calls to U.S. poison control centers increased during 2014—2017, suggesting a possible emerging public health risk. The associated health effects included neurologic, cardiovascular, and gastrointestinal signs and symptoms, with some effects mimicking opioid toxicity and withdrawal.
What are the implications for public health practice?
Health care provider and public education about adverse effects associated with tianeptine use is warranted. Health care providers and public health officials need to report adverse effects to the FDA MedWatch reporting system and contact poison control centers for clinical guidance.
Tianeptine (marketed as Coaxil or Stablon) is an atypical tricyclic drug used as an antidepressant in Europe, Asia, and Latin America. In the United States, tianeptine is not approved by the Food and Drug Administration (FDA) for medical use and is an unscheduled pharmaceutical agent* (1). Animal and human studies show that tianeptine is an opioid receptor agonist (2). Several case studies have reported severe adverse effects and even death from recreational abuse of tianeptine (3—5). To characterize tianeptine exposures in the United States, CDC analyzed all exposure calls related to tianeptine reported by poison control centers to the National Poison Data System (NPDS)†during 2000—2017. Tianeptine exposure calls, including those for intentional abuse or misuse, increased across the United States during 2014—2017, suggesting a possible emerging public health risk. Most tianeptine exposures occurred among persons aged 21—40 years and resulted in moderate outcomes. Neurologic, cardiovascular, and gastrointestinal signs and symptoms were the most commonly reported health effects, with some effects mimicking opioid toxicity. A substantial number of tianeptine exposure calls also reported clinical effects of withdrawal. Among 83 tianeptine exposures with noted coexposures, the most commonly reported coexposures were to phenibut, ethanol, benzodiazepines, and opioids.
For complete article https://www.cdc.gov/mmwr/volumes/67/wr/mm6730a2.htm
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Prescription-only drugs being sold by online doctor sites (August 2018)
Some online doctor sites are selling prescription-only medications to potentially vulnerable patients, a BBC Panorama investigation has found.
Nikki, who suffered with addiction to prescription painkillers after an operation, and Eleanor who had anorexia as a teenager, were both able to buy prescription drugs online. Both women checked with their GPs before agreeing to help Panorama.
The Care Quality Commission, England\’s healthcare regulator, advises patients to only use sites that are registered with it.
Fentanyl and cocaine drug deaths rise
August 2018
I’m Sorry – Whose Fault is this????
The number of deaths in England and Wales due to the synthetic opioid fentanyl rose by 29% in 2017, Office for National Statistics data shows.
Forms of the drug – used to treat cancer pain – are often imported illegally from Chinese laboratories and sold to users via the dark web.
Deaths from psychoactive substances like spice or mephedrone halved.
Drug policy campaigners called on the government to fund drug treatment and stop criminalising users.
\”The UK government has nowhere left to hide. They are responsible for vulnerable people dying in droves,\” Martin Powell from Transform Drug Policy Foundation said.
He accused politicians of blocking, or refusing to fund, measures proven to save lives in other countries.
Last year heroin and morphine related deaths decreased for the first time since 2012, while cocaine deaths rose.
In total, 3,756 people were recorded as dying from legal and illegal drugs in England and Wales in 2017. The ONS said this figure had \”remained stable\”, with only 12 more deaths than the year previous.
For more https://www.bbc.co.uk/news/uk-45083167
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Tesla whistleblower claims its staff in Nevada trafficked cocaine and meth for a Mexican drug cartel and covered up the theft of $37m in raw materials
- Karl Hansen made the series of extraordinary claims in a public letter Thursday
- Claims Tesla investigated DEA tip off but did not disclose the findings to officials
- However, DEA said it would not tell \’non-law enforcement entities\’ about probes
- Hansen also says employees were told not to report huge thefts to the police
- Disgruntled former employee has been called \’super nuts\’ by CEO Elon Musk
- Comes as Tesla shares slumped 8 percent after Musk told of woes in interview
By RORY TINGLE FOR DAILYMAIL.COM August 2018
A Tesla whistleblower is claiming the company covered up drug trafficking at its Nevada gigafactory by employees linked to a Mexican cartel, as well as the rampant theft of raw materials.
Former security guard Karl Hansen says the electric car company launched an \’internal investigation\’ after a May 24 tip-off from the DEA that \’significant amounts\’ of cocaine and crystal meth were being exchanged by staff.
Hansen makes a series of other extraordinary claims in a public letter issued by his lawyers on Thursday, including that Tesla failed to disclose the alleged theft of $37 million in copper and raw materials and spied on staff.
It comes as Tesla\’s shares slumped 8 percent in the wake of a bombshell interview with CEO Elon Musk in which he burst into tears, asked for someone to take his job and admitted he relies on Ambien to sleep.
Musk has dismissed Hansen as \’super nuts\’ and the company issued a statement on Thursday saying some of his claims were \’outright false\’ while others were \’not corroborated\’. They also said Hansen not engaged with their efforts to understand how he had come up with some of the allegations.
Was NOT Tweeting whilst on WEED!! http://www.dailymail.co.uk/news/article-6070421/Elon-Musk-asks-Tesla-job-tearful-interview.html
The PopPot Report on Child Deaths Directly Linked to Marijuana Use.
Use of pot creates victims, including children who die from neglect or violence when parents, mothers’ boyfriends or caregivers use pot. We have been tracking news reports of child abuse and neglect linked to marijuana since November 2012. The columns show official causes of death related to the caregivers’ marijuana use. We found news reports of 112 such deaths in 31 states; actual number could be much higher. Violent neglect includes marijuana DUI (11), guns (5) and pit bulls. The last column includes infants (9) who died shortly after birth.
Middle-class cocaine users helping drug gangs destroy society, says Met chief
Steve Bird 31 JULY 2018
Britain’s most senior police officer has attacked “middle class” cocaine users who worry about “global warming and organic food” but fail to see the harm in illegal drugs.
Cressida Dick, the Metropolitan Police Commissioner, said the demand from well-off users for the class A drug was helping to fuel the surge in violent gang crime.
Her comments came as a top surgeon declared that the whole of England was now in the grip of a knife crime epidemic.
Adam Brooks, a major trauma surgeon at Nottingham University Hospitals NHS Trust, told the Royal Society of Medicine’s Spotlight on Knife Crime: “The key message is this isn’t just London – this is everywhere.”
The conference also heard that paramedics often wear stab vests while treating knife victims because they fear for their safety on the capital’s streets.
Speaking earlier at Scotland Yard, Ms Dick said: “There\’s this challenge that there\’s a whole group of middle class people who will sit round happily talking about global warming, fair trade, environmental protection and organic farming, but think there\’s no harm in taking a bit of cocaine.
“Well, there is. There is misery throughout the supply chain.”
She said she met a \”little girl\” recently who admitted being afraid when having to walk past \”drug dealing paraphernalia\” on the stairs of the flats where she lives.
Ms Dick added that raids targeting gangs dealing drugs and resulted in 79 arrests saw residents “appearing on the balcony, clapping and cheering” officers as they led suspects away.
Ms Dick said that there had been 87 murders in London so far this year, in what she described as part of national trend in rise of violent crime.
For complete article https://www.telegraph.co.uk/news/2018/07/31/middle-class-cocaine-users-care-planet-ignore-drugs-destroy/
Known Cannabis Teratogenicity Needs to be Carefully Considered
Jumping the Gun on ‘Marijuana as medicine’! At What Price?
It is no accident that in almost the same week both Australia and UK have decided that cannabis is to be recommended for a host of medical disorders mostly in advance of gold standard clinical trials. This is a direct product of the organized transnational global drug liberalization movement orchestrated from New York 1.
I wish to most respectfully disagree with the points made by BMJ editor Dr. Godlee. Diarrhoea and colic occur in cannabis withdrawal; Crohn’s disease has a prominent immune aspect, and cannabinoids are likely acting partly as immune modulators. Statements from patients are uninterpretable without understanding the treatments tried, their withdrawal symptomatology and their personal preferences.
Most importantly, as Dr Godlee states, cannabis is a mixture of 104 cannabinoids. The tide cannot be both out and in at the same time. Medicines in western nations are universally pure substances. This comprises a fundamental difficulty.
Medical research has confirmed that the body’s endocannabinoid system is a finely regulated and highly complex system which is involved in the detailed regulation of essentially all body systems including the brain and cardiovascular systems and stem cell niches.
Studies have shown that the rate of use of cannabis by expecting mothers closely parallels that in the wider community. In fact given the long half-life of cannabis in tissues even were a maternal habitual smoker to stop when she discovered her pregnancy, her infant would continue to be exposed to her on-board cannabinoid load for several months afterwards during critical periods of organogenesis. And other studies show that the father’s cannabis use is even more damaging than the mothers’ 2.
For complete article https://www.bmj.com/content/362/bmj.k3357/rr-0
